PTW
  • Users Online: 198
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 13  |  Issue : 2  |  Page : 54-59

Clinicopathological factors predictive of pathological response and impact on disease-free survival in breast cancer: Analysis from a tertiary cancer centre in South India


Department of Radiation Oncology, Government Medical College, Kozhikode, Kerala, India

Correspondence Address:
Dr. Vishnu Asokan
Department of Radiation Oncology, Government Medical College, Kozhikode, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrcr.jrcr_54_21

Rights and Permissions

Aim: Neoadjuvant chemotherapy in carcinoma breast results in tumour downstaging and provides the opportunity to modify treatment based on response. Pathological complete response (pCR) is considered predictive of favourable long-term outcomes. The objective was to identify clinicopathological factors associated with pCR in breast cancer and disease-free survival (DFS). Subjects and Methods: Clinicopathological details of 106 breast cancer patients receiving neoadjuvant therapy were retrospectively analyzed. The statistical analyses were performed using the Chi-square test by SPSS software (version 18.0). Pvalues were considered statistically significant when <0.05. Results: The median age of the patients was 53 years. The overall pCR rate was 23.6%. From univariate analysis, a significant rate of pCR was detected in tumours with high grade or high Ki-67 scores (P = 0.001, P = 0.019), respectively. 29 patients relapsed of which 21 were distant metastasis. On Kaplan–Meier method analysis, statistically significant factors associated with decreased DFS were high Ki 67 and lymphovascular invasion positivity. Distant metastasis occurred in 4 patients with pCR and 19 patients without pCR. The 5-year DFS rate was 84% versus 69% in patients with pCR and without pCR, respectively. Conclusion: A higher rate of pCR was obtained with neoadjuvant therapy in tumours with high grade or Ki-67. Longer DFS is achieved by obtaining pCR with ideal neoadjuvant selection.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed954    
    Printed51    
    Emailed0    
    PDF Downloaded75    
    Comments [Add]    

Recommend this journal