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Year : 2021  |  Volume : 12  |  Issue : 1  |  Page : 1-9

Dosimetric comparison of two type's applicator geometry in the three-dimensional computed tomography image-based intracavitary brachytherapy treatment planning of carcinoma uterine cervix

1 Department of Radiation Oncology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
2 Department of Ratiotherapy, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India
3 Department of Radiotherapy, Indraprastha Apollo Hospitals, New Delhi, India
4 Department of Ratiotherapy, Chirayu Medical College, Bhopal, Madhya Pradesh, India
5 Department of Physics, Government Degree College, Karera, Shivpuri, Madhya Pradesh, India

Correspondence Address:
Dr. Suresh Yadav
Department of Radiation Oncology, Gandhi Medical College, Bhopal, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrcr.jrcr_71_20

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Background: The swift dose fall-off traits with distance from the applicators are the dominant advantage of brachytherapy. The differences in applicator designs will produce different dose distributions in intracavitary brachytherapy (ICBT) applications. Aim: The present study was aimed to find out the dosimetric differences for two type's applicators geometry in ICBT applications for carcinoma uterine cervix (Ca-Cx) performing three-dimensional computed tomography (3D-CT) image-based planning as per recent guidelines from the International Commission on Radiation Units and Measurements report-89. Materials and Methods: Retrospectively, 15 patients of Ca-Cx who have received ICBT treatment based on the 3D-CT image during 1st and 2nd fractions using fixed-geometry and flexible-geometry applicators respectively were selected for this study. For comparison of two type's applicators geometry the dose-volume parameters D100% and D90% of high-risk clinical target volume (HR-CTV), V400%, V200%, V150%, V100%, V50% (volume enclosing 400%, 200%, 150%, 100%, and 50% isodoseline of prescribed dose around target, respectively), and average point “A” dose were evaluated for target. While for organs at risk (bladder, rectum, and sigmoid colon) the dose-volume parameters D2cc, D1cc, and D0.1cc were recorded and evaluated. Results: Fixed-geometry applicator produces significantly lesser HR-CTV volume (P = 0.016 <0.05) but delivered significantly 10.88% higher D90 mean doses (P = 0.031 <0.05) in comparison to flexible-geometry applicator. The flexible-geometry applicator created significantly higher central dose-volume structures around the target at the cost of significantly 15.89%, 17.04%, and 18.88% higher mean doses for rectum D2cc, D1cc, and D0.1cc, respectively, insignificant higher bladder dose, but lower sigmoid colon doses. Conclusion: The results of this study will be helpful to clinicians to select appropriate/suitable geometry applicator according to the patient's anatomical structure in brachytherapy treatment of Ca-Cx for better clinical outcome.

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