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  Indian J Med Microbiol
 

Figure 7: Anatomical and histologic assessment of the effect of sodium salt of SCR7-pyrazine on the progression of tumor in mice and toxicity studies in normal mice. (a) The gross appearance of different organs of normal animals (without tumor), control animals bearing Ehrlich ascites carcinoma tumor and sodium salt of SCR7-pyrazine treated (10 mg/kg) tumor animals on the 25th day of the treatment. (A) thigh tissue of normal mouse, (B) solid tumor tissue, (C) thigh tissue of the sodium salt of SCR7-pyrazine treated mouse, (D) liver from normal mouse, (E) liver of a tumor mouse, (F) liver from sodium salt of SCR7-pyrazine treated mouse, (G) spleen of a normal mouse, (H) spleen of a tumor-bearing mouse, (I) spleen of sodium salt of SCR7-pyrazine treated mouse. (b) Histological analysis of sodium salt of SCR7-pyrazine treated tumor mice. Hematoxylin and Eosin stained sections prepared from either tumor tissues (top) or liver (bottom), with and without treatment of sodium salt of SCR7-pyrazine and normal control animals. (c) Evaluation of side effects of sodium salt of SCR7-pyrazine in normal Swiss Albino mice. Sodium salt of SCR7-pyrazine was administered intraperitoneally (10 mg/kg, six doses every alternate day) to normal (n = 5) and sodium salt of SCR7-pyrazine treated animals (n = 5) and body weight was monitored on the 25th day of treatment. Besides, blood was drawn; plasma and serum were separated, from treated animals along with controls. The serum was analyzed for alkaline phosphatase, creatinine and urea levels. Plasma was also used for counting red blood cells and white blood cells to analyze the side effects. All the values of serum tests and blood counts are given with mean ± standard error of mean (n = 5) and average body weight of each group was plotted with standard error bars. Error bars indicate standard error of mean based on independent experiments. P value represents * P < 0.05; NS: Non-significant

Figure 7: Anatomical and histologic assessment of the effect of sodium salt of SCR7-pyrazine on the progression of tumor in mice and toxicity studies in normal mice. (a) The gross appearance of different organs of normal animals (without tumor), control animals bearing Ehrlich ascites carcinoma tumor and sodium salt of SCR7-pyrazine treated (10 mg/kg) tumor animals on the 25<sup>th</sup> day of the treatment. (A) thigh tissue of normal mouse, (B) solid tumor tissue, (C) thigh tissue of the sodium salt of SCR7-pyrazine treated mouse, (D) liver from normal mouse, (E) liver of a tumor mouse, (F) liver from sodium salt of SCR7-pyrazine treated mouse, (G) spleen of a normal mouse, (H) spleen of a tumor-bearing mouse, (I) spleen of sodium salt of SCR7-pyrazine treated mouse. (b) Histological analysis of sodium salt of SCR7-pyrazine treated tumor mice. Hematoxylin and Eosin stained sections prepared from either tumor tissues (top) or liver (bottom), with and without treatment of sodium salt of SCR7-pyrazine and normal control animals. (c) Evaluation of side effects of sodium salt of SCR7-pyrazine in normal Swiss Albino mice. Sodium salt of SCR7-pyrazine was administered intraperitoneally (10 mg/kg, six doses every alternate day) to normal (<i>n</i> = 5) and sodium salt of SCR7-pyrazine treated animals (<i>n</i> = 5) and body weight was monitored on the 25<sup>th</sup> day of treatment. Besides, blood was drawn; plasma and serum were separated, from treated animals along with controls. The serum was analyzed for alkaline phosphatase, creatinine and urea levels. Plasma was also used for counting red blood cells and white blood cells to analyze the side effects. All the values of serum tests and blood counts are given with mean ± standard error of mean (<i>n</i> = 5) and average body weight of each group was plotted with standard error bars. Error bars indicate standard error of mean based on independent experiments. <i>P</i> value represents * <i>P</i> < 0.05; NS: Non-significant