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  Indian J Med Microbiol
 

Figure 6: Effect of sodium salt of SCR7-pyrazine on the progression of tumor in mouse models and its impact on lifespan. The solid tumor was induced in right thigh region of Swiss albino mice by injecting Ehrlich ascites carcinoma (n = 15) or Dalton's lymphoma (n = 12) cells. Six doses of sodium salt of SCR7-pyrazine (10 mg/kg b. wt.) were administered to tumor-bearing mice (n = 5) every alternate day from the 12th day of tumor cells injection, while the untreated tumor control group (n = 5) received 1X phosphate buffered saline injections every alternate day. (a) Ehrlich ascites carcinoma tumor volume was measured (cu. cm.) following sodium salt of SCR7-pyrazine treatment at regular time intervals and presented along with untreated Ehrlich ascites carcinoma tumor control up to the 20th day. A total of 15 animals comprising untreated tumor-bearing animals (n = 5), sodium salt of SCR7-pyrazine treated tumor animals (n = 5), and no tumor animals (n = 5) were used for the current study. Results presented are from two independent batches. Error bars indicate standard error of mean based on independent experiments. P value represents * P < 0.05; **P < 0.01; ***P < 0.001. (b) Kaplan–Meier survival curves of Ehrlich ascites carcinoma tumor mice treated with sodium salt of SCR7-pyrazine and untreated Ehrlich ascites carcinoma control mice bearing tumor. Five animals per group in duplicates were used for the study. (c) Graph showing tumor volume in mice treated with sodium salt of SCR7-pyrazine. Out of 12, Dalton's lymphoma tumor-bearing animals, 4 served as untreated tumor group, and 4 as sodium salt of SCR7-pyrazine treated tumor-bearing group. Results presented are from two independent batches. Error bars indicate standard error of mean based on independent experiments. P value represents * P < 0.05; **P < 0.01; ***P < 0.001

Figure 6: Effect of sodium salt of SCR7-pyrazine on the progression of tumor in mouse models and its impact on lifespan. The solid tumor was induced in right thigh region of Swiss albino mice by injecting Ehrlich ascites carcinoma (<i>n</i> = 15) or Dalton's lymphoma (<i>n</i> = 12) cells. Six doses of sodium salt of SCR7-pyrazine (10 mg/kg b. wt.) were administered to tumor-bearing mice (<i>n</i> = 5) every alternate day from the 12<sup>th</sup> day of tumor cells injection, while the untreated tumor control group (<i>n</i> = 5) received 1X phosphate buffered saline injections every alternate day. (a) Ehrlich ascites carcinoma tumor volume was measured (cu. cm.) following sodium salt of SCR7-pyrazine treatment at regular time intervals and presented along with untreated Ehrlich ascites carcinoma tumor control up to the 20<sup>th</sup> day. A total of 15 animals comprising untreated tumor-bearing animals (<i>n</i> = 5), sodium salt of SCR7-pyrazine treated tumor animals (<i>n</i> = 5), and no tumor animals (<i>n</i> = 5) were used for the current study. Results presented are from two independent batches. Error bars indicate standard error of mean based on independent experiments. <i>P</i> value represents * <i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001. (b) Kaplan–Meier survival curves of Ehrlich ascites carcinoma tumor mice treated with sodium salt of SCR7-pyrazine and untreated Ehrlich ascites carcinoma control mice bearing tumor. Five animals per group in duplicates were used for the study. (c) Graph showing tumor volume in mice treated with sodium salt of SCR7-pyrazine. Out of 12, Dalton's lymphoma tumor-bearing animals, 4 served as untreated tumor group, and 4 as sodium salt of SCR7-pyrazine treated tumor-bearing group. Results presented are from two independent batches. Error bars indicate standard error of mean based on independent experiments. <i>P</i> value represents * <i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001