Close
  Indian J Med Microbiol
 

Figure 8: The RAD-15 inhibitor B02 induces sterility in Caenorhabditis elegans when organic cation transporter 2 is upregulated. (a and b) Ligand-protein docking of organic cation transporter-1 and organic cation transporter-2 modeled with B02 and binding of the drug to organic cation transporter 2. (c) B02 causes embryonic lethality (diminishing number of germ cells) in the organic cation transporter 1 null mutant. (d) Organic cation transporter 2 downregulation in the organic cation transporter 1 null mutant animals restores fertility. (e) B02 diminishes the number of viable animals when organic cation transporter 2 is expressed. Brood size analysis of the indicated genotypes without and 5 μM B02. (f) The RAD-51 inhibitor, B02, mode of action in Caenorhabditis elegans germline. Reproduced with permission

Figure 8: The RAD-15 inhibitor B02 induces sterility in <i>Caenorhabditis elegans</i> when organic cation transporter 2 is upregulated. (a and b) Ligand-protein docking of organic cation transporter-1 and organic cation transporter-2 modeled with B02 and binding of the drug to organic cation transporter 2. (c) B02 causes embryonic lethality (diminishing number of germ cells) in the organic cation transporter 1 null mutant. (d) Organic cation transporter 2 downregulation in the organic cation transporter 1 null mutant animals restores fertility. (e) B02 diminishes the number of viable animals when organic cation transporter 2 is expressed. Brood size analysis of the indicated genotypes without and 5 μM B02. (f) The RAD-51 inhibitor, B02, mode of action in <i>Caenorhabditis elegans</i> germline. Reproduced with permission