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   Table of Contents - Current issue
October-December 2019
Volume 10 | Issue 4
Page Nos. 155-186

Online since Friday, February 14, 2020

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Hyperthermic oncology, it is time of resurrection p. 155
Nagraj Gururaj Huilgol
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Heat generation from magnetic fluids under alternating current magnetic field or induction coil for hyperthermia-based cancer therapy: Basic principle p. 156
Rashmi Joshi, Ramaswamy Sandeep Perala, Manas Srivastava, Bheeshma Pratap Singh, Raghumani Singh Ningthoujam
Superparamagnetic particles (SUPs) have been used in many applications in the area of hyperthermia-based cancer treatment, as a magnetic resonance imaging contrast agent, as a carrier for drug, in the removal of toxic ions, etc. When SUPs are dispersed in liquid, they can experience Brownian motion and Néel's spin relaxations. In the presence of direct current magnetic field, SUPs do not show a hysteresis loop. Because of this, they are unable to produce heat. However, in alternating current magnetic field (AMF) of a few kHz and small magnetic fields, they can generate heat. For the treatment of cancer, hyperthermia temperature of 43°C is required, at which temperature cancer cells can be killed selectively, but normal cells can survive. The theory behind heat generation from SUPs in the presence of AMF will be discussed in this work.
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Promising role of hyperthermia concurrent with radiation in the treatment of head-and-neck cancers: A retrospective comparative study p. 165
Nagraj G Huilgol, Gopal Pemmaraju, Rohit Dusane
Aim: We aimed to investigate retrospectively the cases of head-and-neck cancer treated with hyperthermia along with radiation in comparison with chemoradiation in terms of local control, survival, and toxicities. Materials and Methods: One hundred twenty-seven cases of head-and-neck cancer who were treated in our department during the period of 2005–2017 with radiation, chemotherapy, and hyperthermia were analyzed. All the patients underwent radiation treatment on Elekta Precise with 6 MV photons to a planned dose of 66–70 Gy. Hyperthermia was delivered on modified Thermatron, Japan, which is a radio frequency-based heating device operating at 9 MHZ. Hyperthermia was initiated after precooling for 5–10 min and impedance matching. The input energy was gradually raised over 2–3 min to the tolerance limits. Input varied from 400 to 800 kW. Cases enrolled in the CTRT group were 74, whereas 53 cases were in HTRT group. Results: In CTRT group, 49 (66.2%) cases had complete response as compared to 48 (90.6%) cases in HTRT group with statistical significance with P= 0.001. Kaplan–Meir survival curve showed a statistical benefit in those treated with CTRT over HTRT. The mean survival in HTRT group was 45.3 months and the median survival was 41.7 months. In the CTRT group, the median survival was 51.5 months and the mean survival was 55.6 months. However, more patients were lost to follow-up in the HTRT group. The difference between median survival times between CTRT and HTRT groups was more than 3 months and 10 days. Conclusion: Combining hyperthermia with radiation gives better results in terms of response, toxicities, and survival and can be used in the treatment of head-and-neck cancer patients in all stages. Better patient follow-up would have given much accurate data for the analysis of toxicities.
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Hyperthermia therapy of cancer: Need for deeper biological insights for improved therapeutic outcome p. 170
Neena G Shetake, BN Pandey
Hyperthermia is the most ancient cancer treatment modality used much before even the discoveries of conventional therapeutic modalities such as radiotherapy. Since then, as a cancer therapeutic modality, hyperthermia has seen several advancements, but an upsetting decline in its recognition in last few decades. Currently, majority of the laboratories working in the research field are engaged in developing combinatorial strategies for hyperthermia along with radiation/anticancer agents. For the targeted delivery of therapeutic agents, several nano-formulations have been developed. In recent years, magnetic nanoparticle-based “nanothermotherapy” is getting the attention of researchers. Unfortunately, despite several successful clinical studies, hyperthermia could not get its due acclaim in cancer therapeutics. In the last few decades, mechanistic insights achieved using cutting-edge technologies opened several therapeutic avenues of many diseases including cancer. However, for many reasons, hyperthermia scientists could not match the pace to tap the knowledge for deeper mechanistic insights. Key questions, such as epigenetic changes, role of immune cells/abscopal effects in hyperthermia, and thermo resistance, still needs to be addressed in depth. It is noteworthy to mention that a deeper mechanistic insight shall contribute immensely in hyperthermia-based cancer therapy not only through overcoming thermoresistance but also through assisting in developing novel thermosensitizers and thermotherapy protocols.
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Abstracts of 11th biennial conference of indian association of hyperthermic oncology and medicine, february 15-16, 2020, Nanavati Hospital, Mumbai p. 174

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Hyperthermic oncology from bench to bedside p. 186
Nagraj Gururaj Huilgol
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