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Year : 2019  |  Volume : 10  |  Issue : 4  |  Page : 186

Hyperthermic oncology from bench to bedside

Division of Radiation Oncology, Nanavati Hospital, Mumbai, Maharashtra, India

Date of Submission03-Feb-2020
Date of Acceptance03-Feb-2020
Date of Web Publication14-Feb-2020

Correspondence Address:
Dr. Nagraj Gururaj Huilgol
Division of Radiation Oncology, Nanavati Hospital, Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrcr.jrcr_6_20

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How to cite this article:
Huilgol NG. Hyperthermic oncology from bench to bedside. J Radiat Cancer Res 2019;10:186

How to cite this URL:
Huilgol NG. Hyperthermic oncology from bench to bedside. J Radiat Cancer Res [serial online] 2019 [cited 2020 Jul 10];10:186. Available from: http://www.journalrcr.org/text.asp?2019/10/4/186/278411

Editors: Satoshi Kokura, Toshikazu Yoshikawa, Takeo Ohinishi

Edition: First Edition

Publishers: Springer

Publish Year: 2016

ISBN: 978-981-10-0717-0, 978-981-10-0719-4

DOI: 10 1007/978-981-10-0719-4

The comprehensive book on hyperthermia was compiled and published by Springer to celebrate the accomplishments of Japanese Society for Thermal Medicine and the 15th International Congress of Hyperthermic Oncology. Naturally, the contributors are from Japan. The book starts with biological basis of hyperthermia after mandatory acknowledgement of ancientness of heat as a therapeutic agent. The first section, “Basic science in cultured cells,” deals with heat-induced oxidative stress, apoptosis, and molecular basis of thermal injury, heat shock proteins, cellular responses in signal transaction pathways induced hyperthermia, cell cycle response to hyperthermia, DNA repair, and thermal tolerance. Each of the chapter is brief with adequate references.

The first chapter showcases the current understanding of the biological rational for hyperthermia of cancer.

Emphasis on DNA damage and repair stands out. Its impact has been revealed, yet it is mired in contrues. The role of oxidative stress in inducing apoptosis by hyperthermia alone highlights a mechanism of action which has not received adequate attention in the past. Similarly a relationship between heat sensitively and DNA damage is unique to the book. Role of DNA that is Deoxy Ribonucleic Acid damage due to hyperthermia has been mired in controversy. Research from Ohinishi and Toshikazu laboratory demonstrate the induction of DSB that is double strand breaks. The chapter also deals with DNA that is Deoxy Ribonucleic Acid repair and inhabitation of repair following hyperthermia. The chapter on immunotherapy is timely. It adds to the current excitement with immunotherapy.

More sensitive and specific methods to detent Deoxy Ribonucleic Acid (DNA) Double Strand Breaks (DSBs) and Single Strand Breaks (SSB) directly may be required to settle this long-standing dispute; this caveat puts the chapter on molecular damage in perspective. The chapter on gene expression patterns and signal transduction is a welcome addition as earlier books on hyperthermic lack this information. The chapter on thermal tolerance is very brief to be comprehensive.

The section on clinical experience is Japan centric. Almost all cancers of different anatomical sites have been included. Inclusion of recently published meta-analysis or a comprehensive review of the clinical trials would have enhanced the relevance of the chapters on clinical sciences. The section on technology is complete though not comprehensive. The book ends with an epilogue which exudes guarded optimism. An excellent collection of articles compiled to celebrate JSTM. A recommend reading.


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