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Year : 2019  |  Volume : 10  |  Issue : 4  |  Page : 165-169

Promising role of hyperthermia concurrent with radiation in the treatment of head-and-neck cancers: A retrospective comparative study

1 Department of Radiation Oncology, Nanavati Superspeciality Hospital, Mumbai, Maharashtra, India
2 Department of Advanced Centre for Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Nagraj G Huilgol
Department of Radiation Oncology, Nanavati Superspeciality Hospital, Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrcr.jrcr_3_20

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Aim: We aimed to investigate retrospectively the cases of head-and-neck cancer treated with hyperthermia along with radiation in comparison with chemoradiation in terms of local control, survival, and toxicities. Materials and Methods: One hundred twenty-seven cases of head-and-neck cancer who were treated in our department during the period of 2005–2017 with radiation, chemotherapy, and hyperthermia were analyzed. All the patients underwent radiation treatment on Elekta Precise with 6 MV photons to a planned dose of 66–70 Gy. Hyperthermia was delivered on modified Thermatron, Japan, which is a radio frequency-based heating device operating at 9 MHZ. Hyperthermia was initiated after precooling for 5–10 min and impedance matching. The input energy was gradually raised over 2–3 min to the tolerance limits. Input varied from 400 to 800 kW. Cases enrolled in the CTRT group were 74, whereas 53 cases were in HTRT group. Results: In CTRT group, 49 (66.2%) cases had complete response as compared to 48 (90.6%) cases in HTRT group with statistical significance with P= 0.001. Kaplan–Meir survival curve showed a statistical benefit in those treated with CTRT over HTRT. The mean survival in HTRT group was 45.3 months and the median survival was 41.7 months. In the CTRT group, the median survival was 51.5 months and the mean survival was 55.6 months. However, more patients were lost to follow-up in the HTRT group. The difference between median survival times between CTRT and HTRT groups was more than 3 months and 10 days. Conclusion: Combining hyperthermia with radiation gives better results in terms of response, toxicities, and survival and can be used in the treatment of head-and-neck cancer patients in all stages. Better patient follow-up would have given much accurate data for the analysis of toxicities.

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