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Year : 2019  |  Volume : 10  |  Issue : 3  |  Page : 135-140

A prospective study comparing hemoglobin levels and response in patients of locally advanced carcinoma cervix receiving accelerated chemoradiation versus conventional chemoradiation

Department of Radiation Oncology, Tertiary Cancer Care Centre, IGMC, Shimla, Himachal Pradesh, India

Correspondence Address:
Dr. Poorva Vias
Department of Radiation Oncology, Tertiary Cancer Care Centre, IGMC, Shimla, Himachal Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrcr.jrcr_17_19

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Introduction: Carcinoma cervix still forms a major burden in India; also, anemia is seen commonly in Indian females. Hemoglobin (Hb) level is one of the prognostic factors in carcinoma cervix. The association of Hb levels with response is not well established. However, Hb levels >11 g% have shown good response in a number of studies. Materials and Methods: This study enrolled patients with carcinoma cervix, <70 years old with Stage IIA to IVA, histologically squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. Accelerated concurrent chemoradiotherapy 50 Gy in 25# 6 days a week with weekly cisplatin was given in the study arm. In the control arm, conventional chemoradiation was given, 50 Gy in 25# five fractions per week with weekly cisplatin. Response was compared in both the arms based on Hb levels. Both the arms had 45 patients. Results: Combining patients of both the arms, 66% of patients with Hb <11 had complete response (CR) and 81% of patients with Hb >11 had CR which was not significant, but a trend of better response was seen toward patients with higher levels of Hb. However, no significant difference was seen in both the arms. Conclusion: Hb levels remain a prognostic factor for carcinoma cervix, but the levels of Hb are still debatable. More prospective studies are needed to assess the effect of Hb. Furthermore, use of erythropoietin and blood transfusions needs to be studied in prognosis of carcinoma cervix.

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