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Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 18-23

Retrospective analysis to assess the effect of hyperthermia along with radiotherapy on the outcomes of treatment in locally advanced carcinoma cervix

Department of Radiation Oncology, Nanavati Super Speciality Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Vibha Saluja
Department of Radiation Oncology, Nanavati Super Speciality Hospital, Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrcr.jrcr_9_19

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Aims: The present study was aimed to assess the impact of Hyperthermia along with Radiotherapy on the outcomes of treatment in locally advanced carcinoma cervix. Materials and Methods: Present study is a retrospective analysis of cancer cervix patients treated with radiotherapy and hyperthermia+/- chemotherapy from Jan 2012 to Jan 2018. Total twenty patients were included in this study. Among Twenty patients 12 patients received (HT+RT) while 8 patients received chemotherapy along with hyperthermia and Radiotherapy, (HT+RT+CT). All patients received EBRTdose 50 Gy in 25 fractions and 5 weeks. All patients were prescribed once a week or twice a week hypertermia for 5 weeks along with radiotherapy. Boost was given to primary disease either via brachytherapy or EBRT. Results: Complete response observed 75% of patients in RT+HT group. Similarly in RT+HT+CT group also 75% patients had complete response. Mean overall survival of 46.98 months with a median follow up time of 22 months. On univariate analysis significant impact of Hyperthermia fractions with (Hazard Ratio = 6.426 (95% CI 1.06 – 38.80), P value = 0.021) and radiation boost with (Hazard Ratio = 4.32 (95% CI 0.86 – 21.48), P value = 0.049) observed. On multivariate near about significance for Hyperthermia Fractions once a week as compared to twice a week (Hazard Ratio = 20.08 (95% CI 1.33 – 303.74), (P value = 0.030). Four patients developed pelvic recurrence. Mean recurrence free survival was 41.17 months. Kaplan Meier survival analysis was used as univariate analysis. P- value < 0.05 considered statistical significant. Conclusion: Combination of hyperthermia and radiotherapy shows better over all survival and hyperthermia is good option in patients with locally advanced carcinoma cervix who are not eligible for chemotherapy.

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