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Year : 2017  |  Volume : 8  |  Issue : 1  |  Page : 74-76

Application of radiogenomics in radiation oncology

Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, Tamil Nadu, India

Correspondence Address:
Indranil Chattopadhyay
Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrcr.jrcr_8_17

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Radiotherapy (RT) can be used in the treatment of cancers, instead of surgery to achieve better functional results by using external beam RT and brachytherapy. Elevation of radiation response in tumor cells and reduction of sensitivity to radiation in adjacent normal tissues are the core issues in the radiotherapeutic field of tumor. Radiogenomics addresses possible associations between germline genetic variation and normal tissue toxicity after RT. The objective of radiation genomics is to identify the genetic markers for personalized RT, in which cancer management is formulated so that the treatment plan will be optimized for each patient based on their genetic background. Combinatorial approaches to radiation-induced gene expression study and genome-wide SNP genotype study may discover candidate biomarkers for personalization of RT treatment and identify genetic alterations that affect risk of normal tissue toxicity.

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