Apurinic/apyrimidinic endonuclease 1 performs multiple roles in controlling the outcome of cancer cells toward radiation and chemotherapeutic agents
Many endogenous and exogenous sources produce reactive oxygen species such as superoxide radical anions and hydrogen peroxide that are converted to the highly reactive form, hydroxyl radical. It is th...
The comparison of genetic instability in haploid and diploid yeast cells exposed to ionizing radiations of different linear energy transfer and ultraviolet light
Context: It is analyzed whether genetic instability is determined by cell ability to recover from radiation damage or it is mainly determined by cell ploidy. The values of the RBE of α-par...
Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in breast cancer cell line
Purpose: Valproic acid (VPA) is used mainly for the treatment of epilepsy and other seizure disorders, however, it is known to be one of histone deacetylase (HDAC) inhibitors. HDACIs have repre...
Inhibitor of nonhomologous end joining can inhibit proliferation of diffuse large B-Cell lymphoma cells and potentiate the effect of ionization radiation
Aim: Diffuse large B-cell lymphoma (DLBCL) is the most common and aggressive type of non-Hodgkin's lymphoma that accounts for ~40% of all lymphomas. DLBCL is considered to be clinically...
A systematic organization of bioinformatics database of radiosensitizers and radioprotectors
Radiosensitizers and radioprotectors are the compounds that modify the radiation therapy treatment. Radiosensitizers make tumor cell more sensitive to radiation therapy which increases the effectivene...
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Journal of Radiation and Cancer Research, a publication of Society for Radiation Research, is a peer-reviewed online journal with Quarterly print on demand compilation of issues published. The journal’s full text is available online at http://www.journalrcr.org
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